Respond to the need behind the profile
A user's immediate task, constraints and objectives are more useful guides to relevance than a fixed persona alone. The same person seeking help with marketing performance may need different answers and proof points when considering brand identity. Their triggers, objections, alternatives and fellow decision-makers can change with the situation, even when their job title stays the same.
Build audience understanding around the conversations people need to have: what prompted their search, what could stop them buying, which alternatives they are considering and what would make an answer credible. Segmentation can remain useful, but a persona should not be the finished answer. For an AI interaction, use the user's stated problem, organisational circumstances and follow-up questions to determine which information deserves attention, rather than assuming everyone in an audience category needs the same response.
Sources: Your audience isn’t a persona. It’s a moving target.